NEUROFENSE® - The Neuro-soothing Natural Concentrate


Saint-Viance, France - February 2018
NEUROFENSE® is an overall natural neuro-soothing active ingredient which enables Caucasian and Asian sensitive skin exposed to cold and pollution to recover comfort and protection.

ACT ON NEURONAL SENSITIVITY - Neutralize the infernal trio of sensitive skin
Every day, external stimuli, such as climate and pollution, cause excessive reactions in sensitive skin. Hyper-reactive, weakened skin is severely put to the test, causing stinging sensations, redness, burning and tightness.

To relieve sensitive skin, SILAB presents NEUROFENSE®, a natural active ingredient targeting the three biological components of skin sensitivity. As a result, NEUROFENSE®:
  • - limits the hyper-reactivity of sensory nerve fibers of the skin [1];
  • - restores the quality of the skin barrier and thus limits the appearance of sensations of tightness, irritation and discomfort;
  • - controls the phenomenon of chronic inflammation that causes itching and redness in sensitive skin [2].
[1] Tested at 0.25%, NEUROFENSE® significantly inhibits the activation of TRPV1 receptors (Transient Receptor Potential Vanilloid 1) (-115%).
[2] Tested at 0.05%, NEUROFENSE® significantly inhibits the secretion of PGE2 by keratinocytes by 95% following treatment with particulate matter. Tested at 0.25% on reconstructed epidermis SILABSKIN® RE subjected to a pollutant stress, it also significantly reduces the synthesis of COX-2 by 34%.

SOOTHE MULTIETHNIC SENSITIVE SKIN - Limit the cutaneous reaction to external stresses
Tested at 2.5% on in vivo original models, NEUROFENSE® significantly improves the tolerance threshold of sensitive skin to climatic stress (cold) on the face (+7.5%) and hands (+15.5%). NEUROFENSE® also attenuates the reactivity of skin to cold by reducing the appearance of skin redness (-43%).

Besides, NEUROFENSE® enables to reduce the neuronal hyper-reactivity caused by environmental (pollution) and chemical stresses.

These results are confirmed by volunteers themselves, as more than 94% of them consider their skin to be less reactive and more comfortable, and notice an attenuation of skin redness. Thanks to its multiethnic efficacy, NEUROFENSE® is therefore an essential skin care product for sensitive skin.

BIO-INSPIRING RED SAGE - Adaptability to harsh climatic conditions
NEUROFENSE® is a natural active ingredient derived from the roots of red sage (Salvia miltiorrhiza). This medicinal plant, well known in China for its therapeutic benefits, has a high capacity to resist very low temperatures. Indeed, it is cultivated in Chinese regions where winters are harsh (Sichuan and Shandong). It thus inspired the development of a natural raw material of interest to treat skin discomfort and help reactive skin to cope with unfavorable climatic stimuli.

Developed according to a rigorous eco-design approach, NEUROFENSE® is a patented active ingredient (INCI name: Butylene Glycol & Water & Salvia miltiorrhiza Root Extract), available in aqueous solution (recommended amount: 0.5 to 2%), and compliant with international cosmetic regulations (Europe, United States, Japan, China).

World leader in the engineering of natural active ingredients
SILAB's reputation is based on excellence. An expert in skin biology and in the mastering of plants and biotechnologies for 30 years, this independent French group provides major names in cosmetic and dermo-cosmetic industry with patented and effective active ingredients.

The beauty of healthy skin.
SILAB markets a catalog of almost 100 cosmetic natural active molecules, with scientifically proven functional properties complying with international regulations. They are recognized on the global beauty market for their high level of scientific innovation.

The care of compromised skin.
SILAB softcare, a department fully dedicated to the care of compromised skin, has a strong commitment to health. Intended for the dermo-cosmetic and dermatological markets, its active ingredients respond to cutaneous disorders (atopic dermatitis, etc.) by reactivating the biological mechanisms of healthy skin according to three principles of excellence: Efficacy, Safety and Naturality.

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