J. Caverzan da Silva, P. da Luz Moreira, L. Mussi, W. Magalhães
Over time, physiological changes like the reduction of collagen and elastin production, as well as an overall decrease in skin
metabolism and redox imbalance, result in significant aesthetic changes that include increased skin roughness, wrinkles, loss
of elasticity and firmness, thinning of the skin, and the appearance of age spots. Additionally, bone retraction and the loss of adipose tissue (lipoatrophy) are also factors in the appearance of aging skin. Several studies have shown that the greater the facial lipoatrophy, the older it appears. To restore a more youthful appearance, dermal fillers are injected into the dermis to re-establish the volume lost to lipoatrophy. Seeking a non-invasive alternative to injectable fillers, Cellfie was developed as a plant-based ingredient that offers a precise and efficient delivery system that activates adipogenesis by stimulating adiponectin and PPARγ to ease the signs of aging. Both mediators were evaluated in vitro as well as the adipogenesis effect. A clinical study was performed using the Bio3D Structured-light Scanner to evaluate area, length, and depth of wrinkles on perioral, nasolabial, periorbital wrinkles and smile regions. Cellfie was found to effectively induce adipogenesis – stimulating skin filling and reducing the signs of aging.