E. Bony, I. Renimel-Krolikiewicz, C. Leduc, P. Bedos, P. Schlegel, J.Y. Berthon, E. Filaire
The skin is routinely exposed to stresses from environmental pollution. These repeated and regular exposures can profoundly affectThe skin is routinely exposed to stresses from environmental pollution. These repeated and regular exposures can profoundly affectskin physiology, and may lead to irreversible consequences. We studied the potential of a Schisandra chinensis (S.C.) extract,particularly enriched in lignans, to enhance skin defense mechanisms involved in pollution stress response, with the main pathwaysinvolved in skin being Nuclear Factor Kappa B (NF-kB), DJ-1, the nuclear factor erythroid 2-related factor 2 (Nrf2) and aryl hydrocarbonreceptor (AhR) signaling pathways. Using an in vitro model, we showed that co-treatment with Urban dust and S.C. extract was ableto stimulate the expression of Nrf2 and DJ-1, as well as the decrease of NF-kB and AhR, suggesting that this active extract may providewide protection for skin against daily environmental insults. In a skin equivalent model stressed by Urban dust, the extract provideda global protection of skin components as shown by key proteins involved in the epidermal barrier. Even if further investigations areneeded, we speculate that S.C. extract can be used to buffer the harmful effects of free radicals and enhance the skin barrier,due toair pollutant interactions with the skin, allowing a global preservation of cutaneous structures.