THE BIOTECH DESIGN OF A POSTBIOTIC BY BIOGUIDING
Inspired by a probiotic from desert climates

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For the development of its new care product for dry skin, SILAB Research drew inspiration from the adaptation properties of a plant probiotic (Lactobacillus arizonensis) to a desert climate. This living microorganism colonizes jojoba, a shrub known for its adaptation to extremely dry conditions, as those of the Arizona desert. In order to ensure its survival, this good bacterial species (= probiotic) bioconverts molecules of its host into bioactive metabolites, more commonly called postbiotics.

Based on their recognized expertise in mastering natural, the microbiota and biotechnologies, SILAB teams have reproduced in industrial bioreactors the natural environment of this bacterial species specific to desert climates by growing it in association with its host, jojoba. This targeted bioguiding technology has directly resulted in the production of bioactive molecules that constitute LACTOBIOTYL®.

Advanced analytical techniques have enabled these bioactive molecules to be identified. They are cyclic polyols, osmoprotecting molecules known to regulate the water status of the plant in conditions of drought. In the skin, these molecules directly target dry skin, thereby making LACTOBIOTYL® the ideal care product to treat dry skin.

IMPROVE THE INTEGRITY OF THE SKIN BARRIER
Regulate epidermal homeostasis

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Using a 3D model of reconstructed epidermis subjected to a water stress, SILAB has shown that LACTOBIOTYL® activates mechanisms required to establish an effective barrier function by:

- stimulating epidermal differentiation and cohesion [1];

- optimizing the formation of the lipid cement by activating the expression of the lipid-synthesizing enzymes GBA, ABCA12, FASN;

- reducing transepidermal water losses (-71%).

[1] Tested at 0.2%, LACTOBIOTYL® boosts the synthesis of filaggrin (+98%), of claudin-4 (+97%) and of desmoglein-1 (+163%).

BOOST HYDRATION AND COMPLEXION RADIANCE
A solution targeting dry skin

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LACTOBIOTYL® improves the quality of dry skin (face and hands).

After 28 days of twice daily application to the face of Caucasian volunteers with dry skin, LACTOBIOTYL® at 1% maintains the microbiota’s equilibrium and revitalizes renewal of the cutaneous barrier. Hydration is improved (+16.2%) and complexion radiance is revived, shown by increased reflection by the skin (+7.4%; P < 0.01). This dual hydrating/complexion booster effect was also significantly seen on the face of Asian volunteers.

LACTOBIOTYL® is therefore recommended in all care products for dry skin. This biotech active ingredient is patented (INCI name: Maltodextrin and Lactobacillus Ferment), available as a powder without preservatives (recommended amount: 0.1 to 1%) and compliant with international cosmetic regulations (Europe, United States, Japan, China, etc.).


World leader in the engineering of natural active ingredients
SILAB's reputation is based on excellence. An expert in skin biology and in the mastering of nature and biotechnologies for more than 30 years, this independent French group provides major names in cosmetic and dermo-cosmetic industry with patented and effective active ingredients.

The beauty of healthy skin
SILAB Cosmetics markets a catalog of almost 100 cosmetic natural active molecules, with scientifically proven functional properties complying with international regulations. They are recognized on the global beauty market for their high level of scientific innovation.

The care of compromised skin
SILAB Softcare, a department fully dedicated to the care of compromised skin, has a strong commitment to health. Intended for the dermo-cosmetic and dermatological markets, its active ingredients respond to cutaneous disorders (atopic dermatitis, etc.) by reactivating the biological mechanisms of healthy skin according to three principles of excellence: Efficacy, Safety and Naturality.

www.silab.fr

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