AGREYNIST® is an anti-free radical and pro-pigmenting active ingredient of plant origin, enabling greying hair to return to its natural color without the need of dyeing it.

Double innovation: autophagy and structural quality of hair

Greying of hair is an unavoidable phenomenon, however, there is a strong consumer expectation to avoid it with natural solutions. Faced with this observation, SILAB developed AGREYNIST®, a natural active ingredient capable of regulating the biological pathways leading to greying, in particular:  

  • it restores the oxidative balance of hair, a necessary factor of any anti-greying strategy, not only by reducing the formation of free radicals, but also by activating cell detoxification induced by autophagy;
  • it favors repigmentation of the hair fiber by stimulating the synthesis of melanin with its cytoprotective effect;
  • it re-establishes the structural quality of hair (result from an original modeling study*).

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* Using Raman microspectroscopy, SILAB conducted a more detailed analysis of the course of greying and, in a novel way, has shown that there are changes in molecular markers related to biomechanical properties (conformation of proteins) and to the barrier function (organization of lipids) in grey hair.

Visible reduction of the stage of greying

The repigmenting effect of AGREYNIST® was demonstrated on Caucasian and Asian, male and female volunteers. Indeed, a visual scoring by experts on photos highlighted that after 4 months of daily application, AGREYNIST® formulated at 2.5% in a lotion significantly decreases the stage of greying by 20% (P < 0.001) on Caucasian volunteers, corresponding to an average decrease of one stage of greying (result visible in 91% of volunteers).

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A subjective evaluation confirmed these data, as after 6 months of use, 91% of the volunteers reported that they have fewer grey hairs and 88% of them considered that it is an anti-grey hair product.

Detoxifying and pro-pigmenting actions

In order to address effectively the issue of hair greying, SILAB implemented a screening of natural raw materials targeting the indispensable anti-free radical and pro-pigmenting effects.

This work led to the identification of two raw materials: black oat seeds (anti-oxidant and detoxifying) and spiny restharrow roots (pro-pigmenting). The use of green solvents combined with enzymatic bioengineering enabled the optimized extraction of molecules of interest. SILAB thus concentrated and stabilized in AGREYNIST® the complementary efficacies of these two raw materials obtained from a controlled supply chain.

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Spiny restharrow (Ononis spinosa) and black oat (Avena strigosa)

With its protective, detoxifying and repigmenting action, AGREYNIST® (INCI name: Butylene Glycol & Water & Ononis spinosa Root Extract & Avena strigosa Seed Extract) offers a natural solution for grey hair care. Composed of biopeptides and polyphenols, this patented active is available in aqueous solution (recommended amount: 0.5 to 2.5%) and compliant with international cosmetic regulations (Europe, United States, Japan, China, etc.).

World leader in the engineering of natural active ingredients
SILAB's reputation is based on excellence. An expert in skin biology and in the mastering of nature and biotechnologies for more than 30 years, this independent French group provides major names in cosmetic and dermo-cosmetic industry with patented and effective active ingredients.

The beauty of healthy skin
SILAB Cosmetics markets a catalog of almost 100 cosmetic natural active molecules, with scientifically proven functional properties complying with international regulations. They are recognized on the global beauty market for their high level of scientific innovation.

The care of compromised skin
SILAB Softcare, a department fully dedicated to the care of compromised skin, has a strong commitment to health. Intended for the dermo-cosmetic and dermatological markets, its active ingredients respond to cutaneous disorders (atopic dermatitis, etc.) by reactivating the biological mechanisms of healthy skin according to three principles of excellence: Efficacy, Safety and Naturality. 

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