Quorum Sensing Modulation: New Mechanism of Action to Balance the Skin Microbiome Dysbiosis

Microbes communicate with each other to coordinate group behaviors, such as virulence, through a specific communication systemMicrobes communicate with each other to coordinate group behaviors, such as virulence, through a specific communication systemcalled Quorum Sensing. This system is directly responsible of the human microbiome health. The new active QUORA NONIPRCF(INCI name Morinda Citrifolia Cell Culture Lysate), hacks these bacteria communication signals, avoiding the harmful attack ofmicrobes on the skin, that causes acne and other skin conditions. Developed from stem cells from the Noni plant, the ingredientis a metabolome rich in anti-Quorum Sensing molecules, specially designed to act against bacterial dysbiosis, blocking themicrobial communication signals in a natural way, stopping the development of virulence and perfecting, at the same time, theskin appearance. The active doesn´t contain antibiotics, thus avoiding the potential development of microbial resistance, and itis also bacteriostatic, maintaining a healthy microbial balance. A full panel in vitro and in vivo studies was carried out, demonstratingthese claims, and the high efficacy of the active against acne.