DE 
Vytrus Biotech, the company specialized in active ingredients derived from plant biotechnology for skin and hair care, proudly announces that its latest innovation CLARIVINE™ – Fasting for Skin Longevity has been awarded the Silver Innovation Award at in-cosmetics Global 2025. This recognition highlights the company’s scientific excellence and commitment to pioneering innovation in sustainable skincare.
Developed through a unique biomimetic mechanism that mirrors cellular fasting in the skin, CLARIVINE™ is a 100% natural active ingredient from Vitis vinífera (grapevine) stem cells, that triggers rejuvenation and detoxification processes at the cellular level. The result is the sought-after glass skin effect, coupled with enhanced long-term skin resilience.
CLARIVINE™ embodies the convergence of major industry trends: natural plant exosomes, cutting-edge biotechnology, and high-performance. It was officially introduced by the Vytrus team during in-cosmetics Global 2025 in Amsterdam, where the company also presented its latest research on the applications of natural plant exosomes for skin and hair care.
Adding to this success, active ingredients CENTELLA REVERSA™ and CAPILIA LONGA™ were also honored with prestigious distinctions at the BSB Innovation Awards 2025—an initiative led by Dr. Jan-H. Riedel that promotes global excellence in cosmetic science. The award ceremony, held on April 8th in Amsterdam, further cements Vytrus’ position as a leader in sustainable, scientifically advanced natural ingredients.
The Plant Fasting Factors: a new approach to skin well-ageing
Fasting has been recognized for its systemic health and longevity benefits. Vytrus’ research and product development aimed to be transfer this principle to the skin – not through diet, but through cosmetics and clinically demonstrated for the first time in cosmetics.
Vytrus has developed a unique fasting-mimicking approach for the skin, inspired by cellular fasting science. This is achieved by inducing a hormetic response induced in Vitis vinifera stem cells through controlled nutrient deprivation. This mild stress stimulates the plant cells to produce a secretome rich in bioactive resilence compounds, what Vytrus defines as the Plant Fasting Factors – a key concept in the biology of skin longevity conformed by:
• Polyphenols and secondary metabolites
• Signaling peptides and proteins
• Natural plant exosomes rich in Exosomic Peptides and Exosomic Resveratrol
These factors activate crucial regenerative pathways such as autophagy, telomere protection, and oxidative stress reduction, improving cellular performance and promoting healthy ageing from within. Skin cells are gently pushed into a rejuvenation mode, detoxifying and renewing themselves naturally.
An innovation inspired by plant longevity
CLARIVINE™ is of 100% natural origin (ISO 16128), COSMOS-approved, China compliant, Halal certified and microbiome compatible and respectful.
This innovative active ingredient is derived from the stem cells of Vitis vinifera , a perennial plant known for its extraordinary lifespan and regenerative capacity. Grapevines are capable of living for centuries – and the secret behind their resilience lies in their ability to adapt to environmental stress.
Through advanced plant biotechnology, CLARIVINE™ introduces an innovative biological approach to promoting skin longevity by mimicking the molecular effects of cellular fasting. This mechanism activates key regenerative pathways that improve skin texture, tone, dark spotsand pigmentation while improving hydration and wrinkles’ appearance at only 14 days. The result is an immediate brightening, rejuvenation and smoothing
effect—the coveted glass skin appearance—combined with scientifically proven cellular longevity benefits, clinically validated in multi-ethnic panels of Asian and Caucasian volunteers.
Vytrus has tapped into this natural intelligence by applying an intermittent fasting protocol to grapevine stem cells, stimulating them to produce a potent fasting-induced secretome. The result is a cutting-edge cosmetic active that bridges two powerful skincare trends: the quest for longevity and the pursuit of glass skin.
CLARIVINE™ represents a new frontier in skincare, offering cosmetic formulators a sustainable, plant-based solution for:
• Smooting, brightening & radiance-boosting formulations
• Skin tone unifying & pigmentation-reducing treatments
• Anti-wrinkle and hydration-enhancing applications
• Glass skin products for long-term well-ageing
Vytrus Biotech is a company specialized in the development, production and commercialization of high added value active ingredients based on plant stem cell culture technology for cosmetic and dermocosmetic industry. Positioning as a pioneer in the use of this technology for business purposes gives Vytrus Biotech a solid foundation on which to build a sustainable competitive advantage. Through this technology, it is possible to obtain natural, patentable, and efficient products. Vytrus has a team of almost 40 employees in its headquarters in Terrassa (Barcelona, Spain) and is present in Europe, USA, LATAM and Asia, among others, through its international network of distributors.
The biotech company has been awarded with 7 international innovation awards for its active Photobiome™, two Best Ingredient Awards at in-cosmetics Latin America and Asia 2022 for its active Elaya Renova™, double ‘Best Ingredient Award’ worldwide at in-cosmetics Global 2020 for two of its ingredients (Kannabia Sense™ and Deobiome Noni™), ‘Gold Best Ingredient Award’ at in-cosmetics Global 2019 for its active Olea Vitae™, amongst other cosmetic awards worldwide.
