ACNESIUM® is a purified natural active ingredient, developed specifically to prevent the clinical signs of slight to moderate acne. Novel models in vitro and in vivo have been used to highlight its efficacy and mechanism of action.

Clinical efficacy

The clinical efficacy of ACNESIUM® is demonstrated under dermatological control in a cohort of adult Caucasian patients suffering from slight to moderate acne.

After 30 days of twice daily application, ACNESIUM® formulated at 0.5% in an emulsified gel significantly decreases the GEA score (Global evaluation acne) and reduces the number of cutaneous lesions, in comparison to the placebo formula.

With this care combining rapidity of action and efficacy, the pathology symptoms are attenuated, the general aspect of the skin is promoted, self-perception is enhanced and patients’ quality of life is improved.

Pharmacological activities

ACNESIUM® restores the homeostasis of acneic skin by targeting the principal abnormalities:

• Colonization by C. acnes is limited by reducing bacterial proliferation, quorum sensing activity and biofilm formation;
• Activity of the sebaceous gland is regulated;
• Inflammation is neutralized by limiting keratinocyte, sebocyte and lymphocyte inflammatory responses;
• Hyperkeratinization is reduced.

Naturality

ACNESIUM® is a natural active ingredient obtained from the pericarps of immature pomegranates (Punica granatum). Indeed, SILAB has demonstrated that the pericarp of immature pomegranates contains a rich and complex mixture of polyphenols whose interest for the optimal and transversal treatment of slight to moderate acne has been shown.

The Punica granatum supply chain of SILAB aims to control and ensure the traceability of the raw material and to secure its supply. Work has been done in close cooperation with producers in order to precisely define the contract conditions of cultures and to guarantee standardization of the quality of the raw material.

ACNESIUM® is composed of ellagitannins, primarily punicalagin and derivatives, as well as punicalin, derivatives of 2,3-(S)-hexahydroxydiphenoyl and ellagic acid.

Safety

ACNESIUM® (INCI name: Maltodextrin & Punica granatum Pericarp Extract) is perfectly tolerated by adult acneic skin. A preservative-free powder (recommended amount: 0.05 to 0.5%) and without harmful or potentially allergenic substances, this active is recommended in dermo-cosmetic facial and body care intended for acneic skin.