An anti-aging active ingredient, ERISIUM® maintains protein balance at the heart of cutaneous cells (or cellular proteostasis) for an anti-wrinkle and radiance booster effect. This protein homeostasis, altered during aging, ensures indeed a firm and radiant skin.

Essential for cell and tissue dynamics

Within cells, the endoplasmic reticulum plays the key role of factory for proteins, essential molecules to ensure the body's vital mechanisms. At the cutaneous level, this optimal functioning translates into a firm and radiant skin. However, a large number of situations of stress can interfere with this protein balance. In response to this, the cell can trigger a “repair function”, namely the UPR (Unfolded protein response).

SILAB has shown for the first time that skin aging disrupts the protein balance (or proteostasis), following highly degraded protein production, and limits the activity of the UPR pathway. Faced with this observation, SILAB Research has developed ERISIUM®, an anti-aging active ingredient that maintains cellular proteostasis by:

- reactivating the UPR pathway and thereby reducing the endoplasmic reticulum stress;

- limiting the inflammaging process;

- restoring matrix dynamics*.

With its action at the heart of the endoplasmic reticulum, ERISIUM® provides a comprehensive antiaging response.

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* In order to confirm these in vitro data on matrix dynamics, SILAB has developed a novel modeling study on Caucasian volunteers, combining LC-OCT and artificial intelligence. The company thus demonstrated the negative impact of aging and photo-exposure on the quality of the dermal matrix and the ability of ERISIUM® to improve skin quality.

Improved skin quality

Tested on Caucasian and Asian panels, ERISIUM® provides an anti-wrinkle and radiance booster effect. Indeed, after 56 days of twice daily application, a visual scoring by trained evaluators using digital photos highlighted that ERISIUM® formulated at 2.5% in an emulsion significantly reduces the stage of wrinkles by 12% (P < 0.01) on Caucasian volunteers (on the crow’s feet), and by 9% (P < 0.01) on Asian volunteers (on the nasolabial fold).

A subjective evaluation confirms these data: at the end of the treatment, 100% of the Caucasian volunteers feel their skin smoother and 100% of the Asian volunteers consider their complexion radiance revived and their wrinkles and fine lines smoothed.

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A bio-inspiring raw material

Following a biomimetic approach, SILAB Research got interested in the outer layers (bran + germ) of rice (Oryza sativa L.). These co-products, resulting from the bleaching of whole grain rice into white rice, are natural sources of essential nutrients (proteins, fibers, inorganic salts, etc.). They are therefore able to maintain a functional protein production in plant cells and to activate the UPR via signal peptides whose enriched sequence in leucine and valine is known to target stressed ER.

In this context, the company has developed a unique enzymatic bioengineering process to specifically extract these leucine- and valine-rich peptides, whose efficacy to restore the UPR pathway in old skin cells has been validated.

With its global anti-aging action, ERISIUM® (INCI name: Oryza sativa (Rice) Extract) is a patented solution of natural origin at 99% (ISO 16128) and respecting biodiversity regulations. Available in aqueous solution (recommended amount: 0.5 to 2.5%) this active ingredient is compliant with international cosmetic regulations (Europe, United States, Japan, China, etc.).


World leader in the engineering of natural active ingredients
SILAB’s reputation is based on excellence. An expert in skin biology and in the mastering of nature and biotechnologies for more than 35 years, this independent French company provides major names in cosmetic and dermo-cosmetic industry with patented and effective active ingredients.

The beauty of healthy skin
SILAB Cosmetics markets a catalog of almost 100 cosmetic natural active molecules, with scientifically proven functional properties complying with international regulations. They are recognized on the global beauty market for their high level of scientific innovation.

The care of compromised skin
SILAB Softcare, a department fully dedicated to the care of compromised skin, has a strong commitment to health. Intended for the dermo-cosmetic and dermatological markets, its active ingredients respond to cutaneous disorders (atopic dermatitis, acne, etc.) by reactivating the biological mechanisms of healthy skin according to three principles of excellence: Efficacy, Safety and Naturality. 

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