Givaudan Active Beauty unveils Silybidiol™, the first globally compliant alternative to the iconic CBD (Cannabidiol) molecule. Designed to combat the harmful effects of urban photo-pollution and promote skin health, Silybidiol™ is extracted from the fruit of the milk thistle with Green Fractionation. It offers a new, holistic approach to ageing, leveraging the emerging concept of OxInflammation, the vicious cycle connecting oxidative stress and inflammation.

In recent years, the perception of skincare and ageing has evolved towards a more positive and resilient approach known as "pre-ageing". This approach emphasises the importance of self-care, focusing on prevention and overall wellbeing. It recognises the link between positive emotional wellbeing and skin condition, promoting skin health and longevity. The exposome - the set of extrinsic aggressors to which our skin is exposed - is an important factor challenging skin health and longevity. It encompasses UV radiation and pollution, which disrupt the skin’s delicate OxInflammation balance - the interconnection of two key biological pathways. These factors can have a damaging cumulative effect on skin health and emotional balance.

Silybidiol™ binds to cannabinoid receptors in the skin and activates cellular crosstalk leading to the activation of skin defences and detoxification pathways to effectively maintain OxInflammation balance and promote wellbeing. Clinically tested versus placebo and CBD, on volunteers exposed to photo-pollution, Silybidiol™ offers:

● A drastic improvement in skin homogeneity (2.7x better than CBD),

● Enhanced skin radiance (1.6x better than CBD),

● An improvement in volunteers’ wellbeing (equivalent to CBD).

"We discovered that Silybidiol™ specifically activates CB2 cannabinoid receptors and delivers the same benefits as the hero CBD molecule. As such, not only does it reduce inflammation, which improves skin tone, but it also stimulates the production of beta-endorphins, feel-good peptides that contribute to overall wellness" comments Romain Reynaud, Research & Development Director. "This dual-action mechanism underlines Silybidiol™'s efficacy in promoting healthy, radiant skin while supporting emotional wellbeing."

Of 100% natural origin ISO 16128 and vegan suitable, Silybidiol™ complies with global standards. It unlocks new perspectives to protect and reverse the consequences of the exposome for all consumers of beauty products. To learn more about our new ingredient, connect to, our digital platform dedicated to cosmetic ingredients.

About Givaudan
Givaudan is a global leader in Fragrance & Beauty and Taste & Wellbeing. We celebrate the beauty of human experience by creating for happier, healthier lives with love for nature. Together with our customers we deliver food experiences, craft inspired fragrances and develop beauty and wellbeing solutions that make people look and feel good. In 2023, Givaudan employed 16,260 people worldwide and achieved CHF 6.9 billion in sales with a free cash flow of 13.3%. With a heritage that stretches back over 250 years, we are committed to driving long-term, purpose-led growth by improving people’s health and happiness and increasing our positive impact on nature. This is Givaudan. Human by nature. Discover more at

About Givaudan Fragrance & Beauty
Givaudan Fragrance & Beauty craft inspired fragrances to perfume lives and memories, and develop innovative beauty and wellbeing solutions that make people look and feel good all over the world. Nature is both our responsibility and our most precious muse. We are just as committed to sustainability as we are to creating innovative products that satisfy consumer needs and anticipate their desires. With a collaborative approach that favours co-creation, we have built a diverse portfolio across personal care, fabric care, hygiene, home care, fine fragrances, and beauty, reflecting our multidisciplinary expertise. This is Givaudan. Human by nature. Learn more at

About Givaudan Active Beauty
Givaudan Active Beauty crafts avant-garde cosmetic actives and high-end specialties that make people look and feel good. We bring nature’s most precious gifts to the art of personal care in the form of biotech & botanical high-performing molecules, delighting consumers. Our extensive portfolio of award-winning skin & hair ingredients spans a variety of benefits for human beauty: from well-ageing and self-tanners to radiance, microbiome-friendly, soothers, hydrators, and more. Backed by solid scientific recognition and consumers’ awareness, we remain at the cutting edge of this rapidly expanding market to deliver sustainable solutions supporting the growth of our customers. This is Givaudan. Human by nature. Learn more at

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