Facial skin is permanently exposed to UV radiation, pollution, and environmental stress, which leads to oxidative and cellular damage. Oxidative stress is one of the main factors of premature skin aging characterized by loss of firmness and elasticity resulting in the appearance of fine lines, wrinkles, and a rougher skin texture. Chronological aging triggers disordered deposition of collagen and elastin fibers which causes the appearance of fine lines and wrinkles. The facial periorbital area (skin around the eyes) is one of the skin sites where the first signs of aging can appear. This skin site is very thin, delicate, and more prone to ageing compared to all other facial areas and requires special care . NaturePepR Ganoderma, part of TRI-K’s NaturePepR Natural Peptides platform, is targeted to the skin around the eyes (specifically crow’s feet) to provide multifunctional skin anti-aging benefits and help repair and prevent skin damage from intrinsic and extrinsic aging. In vitro study results confirm that Ganoderma peptides help repair skin dermal degradation by stimulating the synthesis of extracellular matrix and glycosaminoglycan components, ensuring proper 3D conformational structure, and cross-linking of the collagen fibers, while preventing oxidative and cellular damage caused by chronological aging, UV exposure, pollution, and environmental stress. Clinical efficacy studies prove that Ganoderma peptides reduce crow’s feet wrinkles, skin roughness, and dark spots after only 14 days of treatment, and continue to improve such benefits after 28 days of treatment to create a youthful skin appearance with an even complexion.