Impact of Photostability and UVA/UVA-Blue Light Protection on Free Radical Generation

M. Sohn, S. Krus, K. Jung, M. Seifert, M. Schnyder

The impact of UV-filter combination on the number of free radicals generated in sunscreen formulations and the skin following
UV-VIS irradiation was assessed via electron spin resonance spectroscopy using a spin-probing approach. Four UV-filter
combinations that differed in their photostability and range of UVA absorbance coverage were investigated. Fewer free radicals
were generated in the sunscreen formulation when a photostable UVA filter system was used, compared to a stabilized UVA filter
system. Additionally, fewer free radicals were generated in the skin when a sunscreen with long UVA protection extending to
the short visible range was used, compared to a sunscreen with minimal UVA protection. This study showed that the photostability
of a UV-filter system is central to the generation of free radicals in a formulation, and that long UVA-blue light protection
is key for avoiding the generation of free radicals in the skin. A sunscreen product exhibiting both photostable UVA protection
and long UVA-blue light protection is therefore the most appropriate choice for protecting against ROS-induced skin damage.
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