Bio-based 1,2-alkanediols are ideal ingredients for modern natural cosmetics: they are multifunctional, gentle to the skin and environmentally friendly. Moreover, formulations containing 1,2-alkanediols are typically self-preserving, even at neutral pH. Clever combinations of 1,2-alkanediols with other bio-based additives further increase the mildness of formulations and reduces their cost. In addition, liquid premixes of 1,2 alkanediols and suitable additives also simplify the application and increase productivity. However, to achieve a successful outcome requires making the right choice between different 1,2-alkanediols and different additives. This article shares guidance on the choices available to protect natural cosmetics safely and cost-effectively and includes supportive evidence.