Due to modern lifestyles and the lack of sun exposure, like recently experienced in the pandemic, there is a deficiency of vitamin D. The new active Lithops Pseudotruncatella Callus Lysate stimulates the epidermal cells to stimulate the synthesis of vitamin D and bring beneficial molecules to the skin. Made from Lithops pseudotruncatella stem cells, the active ingredient optimizes the skin microenvironment (strong spatial organization of cell membranes, maximization of light use, deep skin hydration boost and vitamin D activation) to strengthen, volumize, revitalize faded skin and get glowing D-Skin. A new cosmetic concept explained in the present article. Various in vitro and in vivo assays have been carried out to demonstrate the activity and efficacy of the active and the basis of this new concept supported by cosmetic science. A new and healthy way to deal with skin.