Just as the world operates as a vast, interconnected network on a global scale, in the intricate complex fabric of an ecosystem; plants, animals, and microorganisms maintain various interkingdom symbiotic relationships that are essential for the balance and vitality of the entire natural system. 

In a context of green technology development, reverence for nature, and the pursuit of well-being, Provital introduces its groundbreaking ingredient Shiloxome™, the first real ‘ecosystem’ ingredient, which brings together age-defying benefits while protecting the skin in a multi-omic-proven manner.

Crafted through the first-of-its-kind Triplobiome™ Technology, this active ingredient stems from isolating the endophytic yeast Kwoniella mangroviensis found within the protective bark of the cork oak (Quercus suber). Thanks to such symbiotic origin, Shiloxome™ stands as an unparalleled shield, empowering the skin to adapt, thrive, and safeguard itself.

In this article, we provide multi-omic evidence for positive antipollution and well-aging activities of this active ingredient. Results show that this endophytic extract produces a clear rejuvenating effect in vitro and in vivo, significantly improving aspects related to skin healthy appearance. Moreover, this new active ingredient maintains the skin’s natural microbiome which will potentially prevent skin alterations caused by pollution and modulates the lipidome profile towards lipids with longer chains and decreased oxidation, thus improving the protective function of the skin barrier in polluted environments.