Hyaluronic acid (HA) is a very big molecule in the skin which is well-known as a moisturizing factor. It is very important for maintaining skin softness, resilience, volume, and viscosity. However, on top of its moisturizing property, HA plays a very important role in maintaining the structural integrity of the extracellular matrix (ECM) of dermis. With aging, there is a gradual loss of HA in skin which is responsible for the occurrence of wrinkles and sagging. This loss of HA is caused by an enzyme known as HYBID the higher expression of which is highly correlated with skin sagging index and wrinkle depth. Recent studies suggest that HYBID is the main player which is responsible for the degradation of HA in dermis.