The regulation of selected pigments in the EU under the REACH regulation has brought innovations to the tattoo ink segment with new organic compounds. At the same time, as the number of tattooed people in Germany increases significantly, so does the range of tattoo care formulations. However, the impact of the injection of pigment-containing formulations on the skin and the resulting need for protection is difficult to quantify. For this reason, Gematria Test Lab GmbH is dedicated to the assessment of UV-induced radical development in tattoo inks and the effects of tattooing on the skin. For this purpose, pig skin was tattooed and the influence on the intrinsic antioxidant power of the skin and the effect of UV radiation on the skin’s intrinsic free radical formation was determined. The aim is to provide test procedures to identify protection and care strategies for skin modified by tattoos and thereby support the development processes of cosmetic care products. At the same time, the methods presented can help to assess the influence of the application of specific tattoo inks and to minimize the damaging effect on the skin through targeted optimization.