The aim of this study was to compare the effectiveness of both active versions: nature ((-) isomer) and synthetic (racemic mixture (±)) α-bisabolol in the treatment of skin and scalp. Natural version has advantages like being farnesol free, to have the production chain completely transparent and sustainable, in addition of the action potential guaranteed by the presence of the biologically active, that is, the negative isomer (-) in 100% of the composition. Synthetic products, although it is claimed to be similar to natural in the market, have a number of inherent manufacturing problems, such as production being dependent on environmentally and humanly harmful chemicals, difficulty in purification (i.e. product without trace of these compounds), and low efficacy. Furthermore, it is known that micro-organism-dependent technologies are naturally low in yield, requiring high consumption of chemical and biological reagents, which is in disagreement with modern industrial production techniques, in terms of resource savings and natural goods.
On the other hand, the active α-bisabolol: natural ((-) - α-bisabolol) from Candeia tree has been used by the market for decades, with no correlated effects on its use, dissimilar to the synthetic or similar products, with less time in the market, with unknown long-term adverse effects.