Journal Edition sofw journal 5-2019

Introduction

The major disadvantage in dermal drug delivery is the low penetration rate of active ingredients into the skin. To overcome this challenge vesicular carrier systems have gained a wide attention especially in the field of nanotechnology like e.g. liposomes, ethosomes or lipid nanoparticles. Also nanoemulsions are considered to be promising candidates for dermal drug delivery with the advantage of low skin irritation, high drug loading capacity and drug penetration enhancement. Among them new stable anionic nanoemulsions based on the membrane-forming emulsifier “Glyceryl Citrate/Lactate/Linoleate/Oleate”, an eatable and skin friendly emulsifier derived from sunflower, became superior over other vesicular carriers. Depending on the usage of additional emollients/
oils and stabilizers two different emulsions can be obtained: a multiple water-in-oil-in-water nanoemulsion (Hydro-Tops®) or an oil-in-water nanoemulsion (Lipo-Tops®).
 
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