Gattefossé and Ambiotis Jointly Investigated the Mechanisms of Inflammation Resolution During Skin Ageing


Lyon, France - May 9th, 2018
Inflammation is a major concern in dermatology and for skin health. Daily stress, lack of sleep, improper diet, pollution, sun exposure and even ageing can all trigger a lowgrade inflammation in the skin. Inflammation is a natural system of defense against external and internal aggressions. When correctly controlled, inflammation leads to a complete return to tissue equilibrium. However, a default in inflammation resolution pathways may directly impact both appearance and beauty of the skin.

To better understand the muted, asymptomatic and chronic inflammation related to skin ageing, Gattefossé and Ambiotis carried out investigation to unravel the underlying mechanisms leading to non-resolving inflammation, also called Inflamm’ Aging.

A skin explant model was developed in vitro by Gattefossé to simulate the natural triggering of skin inflammation and its subsequent regulation. Using its thorough expertise in metabololipidomic profiling, Ambiotis developed and validated a LC-MS/MS method to monitor the response to inflammation of skin explants and their ability to initiate resolution programs.

Gattefossé and Ambiotis now share technology, expertise and know-how to explore the mechanisms of skin inflammation resolution during ageing. Skin produces bioactive mediators that regulate induction, propagation and resolution of inflammation. Specialized Pro-resolving lipid Mediators (SPMs) are of special importance for an effective resolution of inflammation. Ambiotis and Gattefossé found out that endogenous resolution programs of inflammation were defective in aged skin. Both the dysregulation of lipid pathways and the absence of pro-resolving mediators (e.g. lipoxins) likely lead to an unresolved inflammation in aged skin.

Resolution of inflammation is a complete paradigm shift in the field of inflammation. The discovery of SPMs and their role in the last decade has indeed changed the view to solve inflammatory processes: boosting resolution circuits appears a powerful strategy to rectify chronic inflammatory status. Different approaches can be developed: agonists of resolution targets, mimetics of SPMs… Our company has dedicated its research to the validation of assays to help our partners develop ingredients with pro-resolution capacities. We are very enthusiastic about this collaboration with Gattefossé. This innovative project on skin will open new perspectives for dermo-cosmetic applications”, said Marc Dubourdeau, CEO of Ambiotis.

By performing metabololipidomic profiling of young vs. old skins, followed by a statistical approach using principal component analysis, we have been able to identify the defective elements responsible for unresolved inflammation in aged skins. Our research highlights the need of a new strategy to develop anti-inflammatory molecules, rather focused on boosting resolution than on decreasing inflammation”, said the Skin Biology Research Manager at Gattefossé, Nicolas Bechetoille.

This work will be presented at the 2018 International Investigative Dermatology, Orlando, Florida, US – May 16-19

About Gattefossé
Gattefossé develops, manufactures and sells specialty ingredients for the personal careand pharmaceutical industries and offers a strong expertise in formulation for both of theseactivities.

Gattefossé markets its products in more than 70 countries through 13 affiliated companies and a network of agents and distributors who provide technical and marketing support. Innovation, ethics, quality and long-term stability are the company key-drivers since the beginning.

Gattefossé was founded in Lyon, France in 1880 by Mr. Louis Gattefossé to whom building strong relationship with customers was a priority. The company still is a family-run and independent business, and now employs more than 280 people worldwide.

Since 2007, Ambiotis SAS (Toulouse, France) offers a unique expertise in the field of the resolution of inflammation.

The company provides standardized procedures and tailor-made solutions to bring proofs of concept and decipher mechanisms of action of molecules for its worldwide customers issued from biotech, pharma, dermo-cosmetic and nutraceutic industries.

It currently proposes services for pre-clinical evaluations and analytics for preclinical and clinical samples.

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