Journal Ausgabe sofw journal 7+8-2023

Abstract

Objective: Research evidence supports the skin benefits of Aloe gel in moisturization and healing. However, the market is fraught with aloe gel that is unstandardized, unstable, or unsafe to use.  Thus, it is necessary to provide an aloe gel extract that is safe and stable with demonstrated efficacy. In the present study, AloeHeal™, a stable and standardized, Aloe vera gel extract was developed and tested for its performance in both skincare and oral care applications.

Methods: Aloe vera gel, AloeHeal™ with 0.16% mucopolysaccharide and 0.27% total solid content was extracted by a proprietary mild extraction method. It was further tested for stability (ICH guidelines) and preservative challenge test, PCT, (USP51). The cell proliferative activity, reduction in lipopolysaccharide (LPS)-induced IL-6, and wound healing efficiency were studied in both human gingival fibroblast (HGF) and human dermal fibroblasts (HDF). Finally, AloeHeal™ was evaluated for skin moisturization in a pilot trial (6 volunteers) using Corneometer.

Results: Stability results of AloeHeal™ showed no hydrolysis leading to free sugars. The extract also passed the PCT. In the cell proliferation assay, highest activity was observed at 0.5 mg/ml in both HGF (134.87%) and HDF (142.47%) cells. In addition, at this concentration, 100% wound healing activity was observed in both cell types. AloeHeal™ also showed potent anti-IL-6 activity in HGF (IC50=0.111mg/ml) and HDF (IC50=0.430mg/ml) cell lines. In the pilot in vivo moisturizing study AloeHeal™ retained significant skin moisture for 2 hours as compared to the placebo.

Conclusion: AloeHeal™ is a stable, safe, and efficacious extract of Aloe vera gel with proven skin moisturizing, wound healing, anti-inflammatory, oral-care, and skin rejuvenating ability.

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