•  Preventing the emergence of future expression wrinkles 
  •  Happier smile expression validated by SmiLearning™ smile rating technology 
  •  Powered by Argireline® peptide, delivered through inverse micelle technology 


Preventative botulinum toxin is one of the procedures that is gaining traction among young consumers that are looking for solutions to prevent wrinkles from forming, while achieving a more natural-looking result. 

Argireline® peptide mimics the N-terminal end of SNAP- 25 and it competes with the natural protein for a position in the SNARE complex. If the SNARE complex is slightly destabilized, the acetylcholine filled vesicles cannot release neurotransmitters efficiently and as a result, muscle contraction is attenuated, preventing the formation of lines and wrinkles. 

Argireline® YOUth peptide has been developed for consumers looking to preserve their beauty, including younger generations, and is recommended for oil-based formulations. In vivo, in a foundation, it helped minimize the appearance of expression lines, without compromising the smile expression. In an oil serum, it helped prevent the appearance of expression wrinkles, forehead lines, nasolabial folds and ‘tech neck’ lines. 


65 female and male volunteers of Caucasian and Latin American descent aged between 19 and 35 years old applied a foundation with 2% Argireline® YOUth peptide oil solution or a placebo foundation on the face, once a day for 28 days. 

  • Shorter and less visible wrinkles around the eyes 
    Evaluated during a smile expression by means of a 3D microtopography imaging system based on fringe projection (PRIMOS). 
  • SmiLearning™ smile rating technology based on Deep Learning 
    Deep learning method for facial emotion recognition used to objectively quantify the smile of the volunteers at the end of the treatment. 


60 female and male volunteers of Asian descent aged between 25 and 40 years old applied an oil serum with 0.8% Argireline® YOUth peptide oil solution or a placebo oil serum on the face and neck, twice a day for 28 days. Results were obtained after 7, 21 and 28 days of treatment. 

  • Improved skin profilometry 
    The profilometry of the skin surface was evaluated by means of 3D microtopography imaging system based on fringe projection (PRIMOS). 
  • Minimized appearance of neck folds 
    The improvement in the appearance of wrinkles on the neck fold area was evaluated by a dermatologist through visual scoring. 

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About Lubrizol Beauty

The Beauty business team at Lubrizol Life Science partners with customers and industry leaders to deliver a beautiful skin experience, providing consumers with trending solutions, substantiated benefits and superior sensory enjoyment.

About The Lubrizol Corporation

The Lubrizol Corporation, a Berkshire Hathaway company, leverages its unmatched science and innovation to solve complex challenges for customers, drive sustainable and measurable results and help millions of people, communities and businesses around the world move cleaner, create smarter and live better every day. Founded in 1928, Lubrizol owns and operates more than 100 manufacturing facilities, sales and technical offices around the world and has approximately 8,000 employees.

For more information, visit Lubrizol.com.

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