IFF Promotes Three Women Perfumers to Vice-President Perfumers

IFF today announced the promotion of three perfumers to vice president perfumers: Patricia “Patty” Hidalgo, Joa Kim and Birgit Sijbrands.

» read more

Speaker: Dr. Remo Campiche

Company: DSM Nutritional Products

Title: Establishing the Serine Protease Plasmin as a Pathway for Skin Aging

Language: German

Abstract: Background: Plasmin is a serine protease induced by UV-irradiation. Its activity upregulates pathways such as pro-inflammatory cytokines and matrix-metalloproteinases (MMPs). We showed that plasmin is upregulated in photo-exposed facial skin correlating with increased transepidermal water loss (TEWL). In addition, it is known that the plasminogen system modulates cutaneous melanogenesis. Specific inhibition of the plasminogen system in skin yields positive effects on inflammation, skin hydration and skin resilience.

Objective: Since plasmin activates MMPs and increases inflammation and melanogenesis, we investigated potential skin aging effects of plasmin. In addition, we wanted to show that such effects can be inhibited with a specific plasmin inhibitor.

Methodology: We established in vitro and ex vivo assays to investigate inflammation, MMP-9 activation, collagen degradation, and the melanogenesis modulating activity of plasmin. A specific plasmin inhibitor, Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate (ABSHA), was used in these assays to downregulate those effects. We are completing our investigation with a two month, monocentric, placebo-controlled in vivo study on Chinese female volunteers.

Results: Using pro-inflammatory cytokines, we could upregulate inflammation (via IL-8 or CXCL-5) as well as MMP-9 expression in vitro. Consistent with these data, we could upregulate MMP-9 expression ex vivo using UV-irradiation, resulting in collagen IV degradation. Regarding melanogenesis, we could increase melanin synthesis in vitro by the addition of plasmin to human epidermal melanocytes. All these effects were significantly reduced by a specific inhibitor of plasmin. In addition, we found an increase in collagen I synthesis in dermal fibroblasts when exposed to the plasmin inhibitor. These data are currently investigated in an in vivo study.

Conclusion: Our results establish plasmin as a skin aging enzyme leading to various signs of aging such as wrinkles, sagging and uneven skin tone or age spots. Using specific inhibitors against plasmin such as ABSHA shows promise against age-induced skin conditions.


34th IFSCC CONGRESS is going to be the biggest IFSCC event realized in Brazil. You will experience the Brazilian caring way of holding an event. You will explore papers about biodiversity with focus on technologies that support one world sustainable.

» read more

Product Launches

Evonik has launched Vecollage™ Fortify L, a new vegan collagen for the beauty and personal care market that is identical to collagen in the skin. Vecollage™ Fortify L leverages Evonik’s competencies in biotechnology, collagen, and skin care to meet the demand for...

» read more

sofw Newsletter

Register now and stay tuned!

sofw Messenger

Follow us on social media!

fb in 


Discover current job offers

» All Jobs
Back to top

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.