A New Class of Tyrosinase Inhibitors for Skin Luminosity

Although some skin-lightening cosmetic raw materials already exist, their effectiveness particularly on human tyrosinase has not been directly measured in every case or has not shown convincing performance in-vitro. Some active ingredients are even irritating to the skin and are restricted accordingly by some cosmetics legislations. The search for new, skin-friendlier skin-lightening raw materials has led to the development of promising candidates in recent years. Here we present a barley germ extract containing a new class of active ingredients - hordatines - with superior tyrosinase inhibition properties. The great potential of these molecules was revealed with the help of artificial intelligence by molecular docking to the tyrosinase structure.