Subhead

BASF’s New Anti-Aging Actives Target Epigenetic Mechanisms

Abstract

To explore the field of epigenetics in greater detail, BASF researchers have joined forces and established an interdisciplinary innovation platform. Together with experts from public and private research institutions, they are exploring how modulations to our gene expression, caused by either chronological aging or environmental factors, can be mapped and controlled. BASF’s new anti-aging active ingredients harness the platform’s findings. Dermagenist®, an extract of Origanum majorana leaves, is the first active ingredient that re-activates fibroblasts by protecting them from epigenetic modifications and stimulating their vitality through LOXL1 promoter re-activation. A clinical study demonstrated an 18 % improvement in skin density after two months of application, and a 15 % improvement in skin firmness after three months. RNAge®, an extract of Hippophae rhamnoides seeds, fights chronological microRNA Let-7b dysregulation. BASF has demonstrated that Let-7b is involved in epigenetic regulation and the balancing of proteins in both the extracellular matrix and the proteoglycan network required for a well-balanced dermal structure. RNAge inhibited Let-7b expression by 39 % versus the untreated control. The skin rebuilds from deep within, recovering its density (+26 %) and firmness (+18.5 %) for a healthy and youthful appearance.