Abstract

A novel neurocosmetic soothing active, a biomimetic peptide inspired by the analgesic component of sea anemone venom, immediately comforts sensitive skin after the first application. An in vitro assay showed that the peptide reduced the activation of the TRPV1 pain receptor. To ensure improved skin uptake, the peptide was incorporated into a soft sphere carrier system based on shea butter. In clinical studies, the soothing active increased the electrical current perception threshold of the skin, which is an indicator for reduced skin reactivity and decreased skin sensitivity by reducing the response to skin irritation.